Stemona tuberosa., S. sessilifolia or Stemona japonica  百 部  Bǎi bù  Stemona root   Family: Roxburghiaceae  
PART USED: Root- harvested in Spring before new sprouts have emerged, or Autumn after aerial parts have withered.
Nature- slightly warming   FLAVOR: Pleasant and bitter, sweet CHANNELS: Lung
FUNCTIONS
GROUP: Antitussive and Expectorant Clearing- Clear Breathing
1. Moisten the Lungs and stops coughing.[3] Relieve cough.[1,2] Warms the Lungs.[1] Lubricates the Lung.[2]
2. Destroys intestinal worms.[1] Expels gas.[1]
INDICATIONS
1. Especially useful for cough from deficiency, including that from Yin deficiency.[3] Acute or chronic cough.[2,3] Pulmonary tuberculosis.[1,2] Bronchitis.[1] Pertussis.[1] Whooping cough.[2]
2. Intestinal parasite.[1] Pinworms- as an enema.[1,3]
3. Epidemic diseases.[1]
4. External application for destruction of fleas.[2] Head and body lice.[3]
CONTRAINDICATIONS: Spleen deficiency or loose stools.[3]
PATENT COMBINATIONS
COMBINATIONS
PREPARATIONS: Decoction. Root tubers 9-15 g for each dose. For external use, cook an appropriate amount or steep in alcohol for use as an externally applied agent.[1]  Tuberous root  3-9 g.[2,3]
Used as enema for pinworm.[3] For pinworms use 30-60 g every day for 3 days.[3] Good quality is thick, strong, and solid. The root of S. sessifolia and S. japonica are white that of S. tuberosa is yellowish white.
HABITAT: Grows mostly in thickets on sunny slopes.
DESCRIPTION: Perennial climbing vine. Fleshy root tuber grows horizontally, spindle-shaped or cylindrical. Upper stem section entwining, finely-grooved longitudinally. Leaves; opposite or whorled, broad ovate, apexes acuminate, bases shallowly chordate, margins intact or slightly undulate. Flowers; in spring, single axillary, light purple, appearing on wiry peduncles, base and petiole connected. Capsule; obovate and flat.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Research

Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro.
Lim D, Lee E, Jeong E, Jang YP, Kim J.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Stemona tuberosa (ST) is a traditional herbal medicine used for the treatment of various respiratory diseases in eastern Asia.
AIM OF THE STUDY:
We investigated the anti-inflammatory effects of a ST water extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in cigarette smoke (CS)-induced lung inflammation mouse models.
MATERIALS AND METHODS:
RAW 264.7 macrophages were treated with the ST extract and stimulated by LPS. The expressions of pro-inflammatory mediators were evaluated by using nitric oxide (NO) assay, enzyme-linked immunosorbent assay and Western blot analysis. After the C57BL/6 mice were exposed to CS, they were administrated with the ST extract. The accumulated inflammatory cells in the bronchoalveolar lavage fluid (BALF) were counted. Also, real-time polymerase chain reaction and hematoxylin and eosin staining were performed in lung tissues.
RESULTS:
The ST extract treatment reduced the production of NO via blocking the expressions of cyclooxygenase-2 and inducible nitric oxide synthase protein in RAW 264.7 macrophages. In addition, ST extract treatment decreased the secretions of inflammatory cytokines and regulated NF-κB activation by inhibiting the phosphorylation of IκB and the mitogen-activated protein kinase pathway. Also, ST extract administration to mice reduced the infiltrations of macrophages into BALF and the histological inflammatory changes in lung tissues. Furthermore, administration of the ST extract regulated the levels of tumor necrosis factor-α, interleukin (IL)-6, IL-1β, monocyte chemoattractant protein-1 and matrix metalloproteinases-12 in the lungs.
CONCLUSION:
These findings suggested that ST extract attenuated pulmonary inflammatory responses by inhibiting the expression of diverse inflammatory mediators in vivo and in vitro.
PMID: 25476485 DOI: 10.1016/j.jep.2014.11.032 Ethnopharmacol. 2015 Feb 3;160:41-51. doi: 10.1016/j.jep.2014.11.032. Epub 2014 Dec 2. ncbi.nlm.nih.gov

Two new polyketides from the roots of Stemona tuberosa.
Fang L, Song XQ, He TT, Zhu KK, Yu JH, Song JT, Zhou J, Zhang H.
Abstract
Two polyketides, stemonones A (1) and B (2) with new skeletons, were isolated from the roots of Stemona tuberosa. Their absolute structures were fully characterized by comprehensive spectroscopic analyses and comparison of experimental electronic circular dichroism (ECD) spectra with calculated ones. The plausible biosynthetic pathways for 1 and 2 were also proposed. Anti-inflammatory assay confirmed that the two compounds showed moderate inhibitory effects on β-glucuronidase release in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor.
PMID: 29964177 DOI: 10.1016/j.fitote.2018.06.025 Fitoterapia. 2018 Sep;129:150-153. doi: 10.1016/j.fitote.2018.06.025. Epub 2018 Jun 28. ncbi.nlm.nih.gov

Neuroprotective Bibenzyl Glycosides of Stemona tuberosa Roots
Ki Yong Lee, Sang Hyun Sung, and Young Choong Kim*
Abstract
Three new bibenzyl glycosides characterized as stilbostemin B 3‘-β-d-glucopyranoside (1), stilbostemin H 3‘-β-d-glucopyranoside (2), and stilbostemin I 2‘ ‘-β-d-glucopyranoside (3) were isolated from the roots of Stemona tuberosa. All three bibenzyl glycosides significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
DOI: 10.1021/np0504154
Publication Date (Web): January 31, 2006 J. Nat. Prod. 2006, 69, 4, 679-681 pubs.acs.org