Angelica polymorpha. A.sinensis  当 归 Dāng guī   Angelica   Family: Umbelliferae        
根 Gēn   Root- Harvested at the end of autumn.    
Nature- warm     FLAVOR: Sweet, pungent, bitter pleasant. acrid  CHANNELS: Heart, Liver, Spleen
FUNCTIONS
GROUP: Nourishing Blood
1. Nourish and activate Blood.[1]  Stimulates circulation.[1]
2. Regulate menstruation, relieve pain.
3. Mildly laxative, it also moistens dryness in the system.[1]
INDICATIONS
1. Blood Deficiency a) Manifesting as- Anemia, pallid complexion, blurred vision.
                 b) Causing menstrual problems such as- Irregular Menstruation.[1] Metrorrhagia.[1] Vaginal bleeding. Amenorhea. Dysmenorrhea.
2. Abdominal pain after childbirth.
3. Constipation due to dryness in the intestines caused by Blood deficiency.[1]
4. Channel and passageway obstructions such as rheumatism, boils and ulcers, traumatic injuries, by invigorating the Blood.[1]
PATENT COMBINATIONS
CONTRAINDICATIONS: Use with caution where there is diarrhea or abdominal distention due to Damp obstruction. Yin deficiency with Heat signs.
PREPARATIONS: Decoction- Root 4-12 g. 6-12 g.[1]
Fluid Extract 1:1 in 45% alcohol.[5]
当 归 伟 Dāng guī wěi  Dang Gui Tails (Rootlets)    
PREPARATIONS: These are commonly made into freeze dried powder.
FUNCTIONS
1. The tails are the least tonifying but most activating.[4]
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Research
No estrogenic effect. Contracts uterus muscles if given intravenously to anethetized dogs and rabbits. During labour seems to make contractions more regular. Angelica has a Liver protective effect against CCl4 when fed to mice.

Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway.
Rahman MA, Bishayee K, Huh SO.
Abstract
Angelica polymorpha Maxim root extract (APRE) is a popular herbal medicine used for treating stomachache, abdominal pain, stomach ulcers, and rheumatism; however the effect of APRE on cancer cells has not yet been explored. Here, we examined APRE cytotoxicity seen on target neuroblastoma cells (NB) using cell viability assays, DAPI visualization of fragmented DNA, and Western blotting analysis of candidate signaling pathways involved in proliferation and apoptosis. We demonstrated that APRE reduced cell viability in NB to a greater extent than in fibroblast cells. In addition, we found that APRE could inhibit the three classes of MAPK proteins and could also down-regulate the PI3K/AKT/GSK-3β activity all being relevant for proliferation and survival. APRE could also up-regulate Bax expression and down-regulate Bcl-2 and Mcl-1. With APRE treatment, depolarization of mitochondria membrane potential and activation of caspase-3 was demonstrated in the SH-SY5Y cells. We could not found increased activity of death receptor and caspase-8 as markers of the extrinsic apoptosis pathway for the APRE treated cells. In presence of a caspase-3 siRNA and a pan-caspase inhibitor, APRE could not reduce the viability of NB cells to a significant degree. So we predicted that with APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved. These findings demonstrate that an intrinsic mitochondria-mediated apoptosis pathway mediates the apoptotic effects of APRE on SH-SY5Y cells, and that APRE shows promise as a novel agent for neuroblastoma therapy.
PMID: 26674967 PMCID: PMC4757799 DOI: 10.14348/molcells.2016.2232
Mol Cells. 2016 Feb;39(2):119-28. doi: 10.14348/molcells.2016.2232. Epub 2015 Dec 15. ncbi.nlm.nih.gov

The anti-ulcer activities of bisabolangelone from Angelica polymorpha.
Wang J, Zhu L, Zou K, Cheng F, Dan F, Guo Z, Cai Z, Yang J.
Abstract
AIM OF THE STUDY:
Evaluate the anti-ulcer effects of bisabolangelone from Angelica polymorpha Maxim and provide the basic data to further study for the Angelica polymorpha and bisabolangelone.
MATERIALS AND METHODS:
Bisabolangelone was isolated from Angelica polymorpha Maxim collected from Shennongjia Forest District of China. The structure of bisabolangelone was elucidated by NMR and MS spectrums. The anti-ulcer effects were evaluated with length of lesion (mm) and activity of H(+)/K(+)-ATPase in two models induced by ethanol and Pylorus ligation. Experimental groups were administered with different doses of bisabolangelone (3.8, 7.6 and 15.3 mg/kg). The positive control group was administered omeprazole with a dose of 3.3 mg/kg.
RESULTS:
Bisabolangelone significantly reduced the length of lesion (3.8, 7.6 and 15.3 mg/kg, P<0.01), inhibited the activity of H(+)/K(+)-ATPase (3.8, 7.6 and 15.3 mg/kg, P<0.01), decreased the volume of gastric juice (7.6 and 15.3 mg/kg, P<0.05), and increased the pH value of gastric juice (7.6 and 15.3 mg/kg, P<0.01, 3.8 mg/kg, P<0.05).
CONCLUSIONS:
Bisabolangelone is the main anti-ulcer active compound of Angelica polymorpha, and remarkably preventive and therapeutic action on gastric ulcer. It is possible that bisabolangelone inhibited the activity of the H(+)/K(+)-ATPase, then reducing the secretion of H(+), and the anti-ulcer mechanism of bisabolangelone was deserved to be further studied.
PMID: 19429382 DOI: 10.1016/j.jep.2009.02.048 J Ethnopharmacol. 2009 Jun 22;123(2):343-6. doi: 10.1016/j.jep.2009.02.048. Epub 2009 Mar 14. ncbi.nlm.nih.gov

Effect of extracts of Angelica polymorpha on reaginic antibody production.
Sung CP, Baker AP, Holden DA, Smith WJ, Chakrin LW.
Abstract
An aqueous extract of Angelica polymorpha was examined for its immunoregulating properties. Its effect on the production of antibodies was tested in (C57BL/6 X DBA/2)F1 mice. When the animals were treated daily with the extract, the serum titers of reaginic antibodies normally observed after a single injection dinitrophenylovalbumin (DNP3-OA) were significantly lower, and the higher and more sustained reaginic titers induced by booster injections of DNP3-OA were also inhibited. The immunosuppressive activity was observed both by oral and intraperitoneal administration of the extract, and it was not removed by dialysis. In contrast, the serum titers of IgG were not significantly altered by the administration of the extract. The extract had little or no effect on the passive cutaneous anaphylaxis reaction or the release of histamine from sensitized rat lung fragments.
PMID: 7130985 J Nat Prod. 1982 Jul-Aug;45(4):398-406. ncbi.nlm.nih.gov