Sanguisorba officinalis. S. sinensis  地 榆  Dì yú   Garden burnet, Red Bloodwort  Family: Rosaceae    
PART USED: Root
Nature: Cool    FLAVOR: Bitter, sour, harsh.    CHANNELS: Liver, Large Intestine
FUNCTIONS- Mostly assistant herb
GROUP: Regulating Blood and Styptic
1. Cool Blood.[1] Counteract toxic effects.[1,2] Styptic for gastrointestinal tract.[3]
2. Clear fever.[1] Astringent.[3] Antibiotic.[3]
INDICATIONS
1. Gastro-intestinal bleeding: Bleeding hemorrhoids.[1,2] Uterine bleeding.[1] Bleeding from stomach and intestines. Tenesmus with discharge of blood, vaginal bleeding. Acute bacillary dysentery.[1] Blood in stool from haemorrhoids or ulcer.[3]
2. External application for burns-[1,2,3] can add Shi gao. Also carbuncles.
CONTRAINDICATIONS: Take care with weak Deficient conditions.[3] Deficient Cold conditions.[3]
PREPARATIONS: Decoction. Roots 15-30 g for each dose. Or dried roots may be crushed and taken by mouth; or sesame oil may be mixed with the powdered root for applying on external cuts and injuries.[1]  Dried root 9-15 g.[2,3]

- Chronic dysentery- use roasted Di yu
HABITAT: Grows on uplands and plains.
DESCRIPTION: Perennial herb. Perennial roots thick. Stem; erect, height 20-150 cm, finely angled and shallowly grooved. Leaves; alternate, oddly pinnate compound, leaflets long oval, apexes obtuse, bases truncate, margins serrated. Basal leaves; larger, with long petioles. Stem leaves; smaller, petioles almost absent, bases clasping stem, stipules on both sides encircling. Flowers; in autumn, dark purplish red terminal flowers, obovate or rounded, forming a spike inflorescence. Achene; ovate and 4-angled.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents.
Research.
The antihemorrhagic effect has been demonstrated in animals, and has been shown to be due at least in part to the 3,3'4-tri-O-methylellagic acid.[1]
Burnet has a therapeutic effect on burns and scalds, by reducing exudation, decreasing tissue edema and reducing the incidence of infection. These effects were found to be other factors as well as the tannins.[2]
It has a mild anti-emetic action and antimicrobial activity against a variety of common pathogens.[2]
Clinical studies have confirmed its usefulness in bacillary dysentery, and topically for skin diseases such as eczema and infected tinea pedis.[2]
It is also an ingredient of some Chinese compound preparations which have been tested and found to be effective for cervical erosion, uterine bleeding, and gastrointestinal hemorrhage.[2]
Burnet extract is also an ingredient of a dentifrice used for the prevention and treatment of periodontal disease.[3]
References

Sanguisorba officinalis L. Extracts Exert Antiobesity Effects in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets.
Jung DW, Lee OH2, Kang IJ.
Abstract
The purpose of this study was to investigate the antiobesity effect of Sanguisorba officinalis L. (SOL) in 3T3-L1 adipocytes and obese C57BL/6J mice. SOL was extracted with water and 30%, 50%, 70%, and 100% ethanol (EtOH). 3T3-L1 adipocytes were treated with SOL extracts (100?µg/mL) during the differentiation period. Triglyceride (TG) accumulation was determined by Oil Red O staining, and the expression of adipocyte-specific proteins was measured by Western blot analysis. C57BL/6J mice were fed a high-fat diet to induce obesity and were orally administered SOL 50% ethanol extract (50, 100, and 200?mg/kg) for 8 weeks. Among the SOL extracts, the 50% EtOH extract considerably inhibited TG accumulation through the downregulation of PPAR?, C/EBPa, and SREBP-1c in 3T3-L1 adipocytes. In addition, the 50% ethanol extract reduced body weight and adipose tissue weight and improved serum lipid profiles through downregulation of PPAR?, C/EBPa, FABP4, and ACC and upregulation of adiponectin and CPT-1 in obese C57BL/6J mice fed a high-fat diet. These results suggested that the SOL 50% EtOH extract may have an antiobesity effect through the regulation of transcription factors related to adipogenesis, lipogenesis, and lipolysis.
PMID: 27309406 DOI: 10.1089/jmf.2016.3704  J Med Food. 2016 Aug;19(8):768-79. doi: 10.1089/jmf.2016.3704. Epub 2016 Jun 16. ncbi.nlm.nih.gov

Extracts of medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus type one.
Liang J, Chen J, Tan Z, Peng J, Zheng X, Nishiura K, Ng J, Wang Z, Wang D, Chen Z, Liu L.
Abstract
Highly active antiretroviral therapy (HAART) has been successful in reducing HIV-1-associated morbidity and mortality since its introduction in 1996. It, however, fails to eradicate HIV-1 infection thoroughly. The high cost of life-long HAART and the emergence of drug resistance among HIV-1-infected individuals have brought renewed pressure for the discovery of novel antivirals and alternative medicines. Traditional Chinese medicine (TCM) is one of the mainstreams of complementary and alternative medicine, and serves as rich resources for new drug development. Despite almost 100 plant-derived compounds are in clinical trials, few target HIV-1 infection. In this study, we discovered that extract of Sanguisorba officinalis (SOE) has anti-HIV-1 activities. Using a cell-based assay and single-cycle luciferase reporter viruses pseudotyped with envelopes from HIV-1 or control viruses, we found that SOE exhibited significant inhibitory ability against both CCR5 and CXCR4 tropic HIV-1 (ADA and HXB2) with respective IC50 values of 1.91±0.16 µg/ml and 3.70±0.53 µg/ml. Interestingly, SOE also inhibited SIV infection but failed to block vesicular stomatitis virus (VSV), SARS-CoV and influeunza H5N1 pseudoviruses. Furthermore, we showed that SOE had no effects on post-entry events of HIV-1 replication. It blocked entry by acting on viral envelope directly because SOE pre-treatment with the virus but not with cell lines expressing viral receptors showed the maximal inhibitory activity. In addition, SOE was able to inhibit reverse-transcription-inhibitor-resistant viruses (K103N, Y188L, and K103N/Y188L/G190A) and a protease-inhibitor-resistant strain (PI-2840). Our findings demonstrated SOE as a novel and specific entry inhibitor, which shed lights on the discovery of anti-HIV-1 drugs from traditional herbal medicines.
PMID: 25191092 PMCID: PMC4151571 DOI: 10.1016/j.jfda.2013.09.034  Yao Wu Shi Pin Fen Xi. 2013 Dec;21(4):S52-S58. ncbi.nlm.nih.gov