Peucedanum praeruptorum. P. decursivum  前 胡  Qián hú   Hogfennel root   Family: Umbelliferae     
PART USED: Root- harvested in Winter when the aerial parts have withered.
Nature: Cool    FLAVOR: Bitter, pungent. CHANNELS: Lung
FUNCTIONS
GROUP: Antitussive and Expectorant Clearing- Hot Phlegm
1. Redirects the Qi downward and expels phlegm.[3] Transform sputum.[1,2] Relieve cough.[2]
2. Clears Wind from the exterior.[3] Disperse Wind Heat.[2]
3. Loosens up flatus, clears fevers, lowers excess energy.[1]
INDICATIONS
1. Coughing or wheezing with thick sputum due to Heat in the Lungs.[3] Coughing and asthma.[1] Congested chest.[1] Dysnea.[1,2]
2. Externally contracted Wind Heat or Wind Cold conditions that present with coughing and copious sputum.[3] Most often used in Wind Heat conditions.[3] Colds.[1] Headache.[1]
CONTRAINDICATIONS: According to some traditional sources, this herb counteracts Veratrum nigrum- Li lu
PATENT COMBINATIONS
COMBINATIONS
COMPARISONS
PREPARATIONS: Decoction.  Dry root 5-9 g.[1,2,3]  Good quality is thick, firm, with a firm cortex, yellowish white cross section with many oily spots, and is strongly aromatic.

HABITAT: Grows wild in the sun among damp thickets on hillsides and waste places.
DESCRIPTION: Perennial herb. Roots; thick and sturdy, with remnant fibers of decayed sheaths at base. Upper stem; branching. Basal leaves; rounded to broadly rounded, 2 times pinnately compound, with long petioles, base of petioles enlarging to form sheaths clasping the stem. Stem leaves; smaller, petioles short. Flowers; in autumn, terminal or axillary white flowers appear to form umbellate inflorescences. Fruit; ovate-rounded, 3 angled, marginal lobe developing into wings
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.

Constituents
Research
Research progress of the studies on the roots of Peucedanum praeruptorum

Anti-osteoclastogenic activity of praeruptorin A via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation.
Yeon JT, Kim KJ, Choi SW, Moon SH, Park YS, Ryu BJ, Oh J, Kim MS, Erkhembaatar M, Son YJ, Kim SH.
Abstract
BACKGROUND:
A decrease of bone mass is a major risk factor for fracture. Several natural products have traditionally been used as herbal medicines to prevent and/or treat bone disorders including osteoporosis. Praeruptorin A is isolated from the dry root extract of Peucedanum praeruptorum Dunn and has several biological activities, but its anti-osteoporotic activity has not been studied yet.
MATERIALS AND METHODS:
The effect of praeruptorin A on the differentiation of bone marrow-derived macrophages into osteoclasts was examined by phenotype assay and confirmed by real-time PCR and immunoblotting. The involvement of NFATc1 in the anti-osteoclastogenic action of praeruptorin A was evaluated by its lentiviral ectopic expression. Intracellular Ca(2+) levels were also measured.
RESULTS:
Praeruptorin A inhibited the RANKL-stimulated osteoclast differentiation accompanied by inhibition of p38 and Akt signaling, which could be the reason for praeruptorin A-downregulated expression levels of c-Fos and NFATc1, transcription factors that regulate osteoclast-specific genes, as well as osteoclast fusion-related molecules. The anti-osteoclastogenic effect of praeruptorin A was rescued by overexpression of NFATc1. Praeruptorin A strongly prevented the RANKL-induced Ca(2+) oscillation without any changes in the phosphorylation of PLCγ.
CONCLUSION:
Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation.
PLoS One. 2014 Feb 21;9(2):e88974. doi: 10.1371/journal.pone.0088974. eCollection 2014. ncbi.nlm.nih.gov

Research progress of the studies on the roots of Peucedanum praeruptorum dunn (Peucedani radix).
Song Y, Jing W, Yan R, Wang Y.
Abstract
As a commonly employed traditional Chinese medicine, Peucedani Radix (Qian-hu in Chinese), which consists of the dried roots of Peucedanum praeruptorum Dunn, has a long history of application for the treatment of cough with thick sputum and dyspnea, nonproductive cough and upper air-way infections in traditional medicinal practice. The current review aims to summarize the research progress on the botany, phytochemistry, chemical analysis, pharmacological assay, and pharmacokinetic profile of this famous herbal drug. All available information on this traditional medicine was obtained via electronic search (using ACS, PubMed, Web of Science, Google Scholar, Baidu Scholar, and CNKI). Phytochemical investigations revealed that angular-type pyranocoumarins (APs), mainly (±)-praeruptorin A (Pd-Ia), (+)-praeruptorin A, (±)-praeruptorin B, (+)-praeruptorin B (Pd-II) and (+)-praeruptorin E (Pd-III), were the main active components in Qian-hu, while some other types of ingredients were also identified from this herb. The crude extract and pure compounds from Peucedani Radix exhibited a wide spectrum of in vitro and in vivo pharmacological activities, including vasorelaxant, cardioprotective, hepatoprotective, anti-tumor and anti-platelet aggregative effects. Conversely to the well-defined chemical constituents and activities, the properties of absorption, pharmacokinetics, and metabolism were rarely characterized. However, further investigations are wistful for the development of new drugs and therapies for various diseases, especially cardiovascular disorders. Collectively, the present review on the phytochemistry, chemical analysis, pharmacological evaluation, and pharmacokinetic profile of Peucedani Radix will provide meaningful information for further studies and commercial exploitation of the herbal medicine.
Pak J Pharm Sci. 2015 Jan;28(1):71-81. ncbi.nlm.nih.gov