Oroxylum indicum. 木 蝴 蝶, Mù hú dié,   Qian chen zi  Oroxylum,  Seed of Indian trumpet flower   Family: Bignoniaceae   
PART USED: Dried ripe seed- fruit harvested in Autumn and Winter, dried and cracked open.
Nature: Cool   FLAVOR: Slightly sweet, bitter  CHANNELS: Lungs, Liver, Stomach
FUNCTIONS
GROUP: Antitussive and Expectorant Clearing- Breathing
1. Moistens the lungs,[1,2] and clears the voice.[2]
2. Regulates Liver Qi.[2] Disperse Liver energy congestion, harmonize stomach.[1]
INDICATIONS
1. Laryngo-pharyngitis, cough due to Hot Lungs, pain in ribs, stomach ache.[1] Cough, sore throat and hoarsness.[2]
2. Flank and epigastric pain due to constrained Qi.[2]
3. Topically for healing of ulcerated supporative sores.[2]
COMBINATIONS
PREPARATIONS: Dried ripe fruit 1-3 g.[1] 1.5-6 g.[2] Good quality is large, dry, and white.
    
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Research

Protective effect of aqueous extract of Oroxylum indicum Linn. (root bark) against DNBS-induced colitis in rats.
Joshi SV, Vyas BA, Shah PD, Shah DR, Shah SA, Gandhi TR.
Abstract
OBJECTIVE:
Aqueous root extract of Oroxylum indicum was evaluated in rats against dinitrobenzene sulfonic acid (DNBS) induced colitis.
MATERIALS AND METHODS:
Rats were pre-treated orally for seven days and continued for four days after the induction of colitis with OI(aq) (100, 200, and 400 mg/kg) or vehicle. Colitis was induced by intracolonic instillation of 25 mg of DNBS per rat dissolved in 50% alcohol and 4 days later, the colonic mucosal damage was analyzed along with food intake, body weight, colon weight, spleen weight, histological damage, myeloperoxidase (MPO) activity, malondialdehyde (MDA) levels, reduced glutathione (GSH), and nitric oxide levels in colonic tissue homogenate.
RESULTS:
Significant reduction in gross damage area, weight loss and increase in colonic and spleen weight were evident in test substance-pretreated animals' dose dependently as compared to vehicle treated control. These effects were confirmed biochemically by a reduction in colonic myeloperoxidase activity, malondialdehyde levels, nitric oxide levels, and increase in reduced glutathione (GSH) levels. Furthermore, microscopic examination revealed diminution of inflammatory cell infiltration and submucosal edema in colon segments of rats treated with OI(aq).
CONCLUSION:
The results demonstrate the protective effect of OI(aq) in the animal model of acute colitis possibly through an antioxidant, anti-lipoperoxidative or due to reduction in nitric oxide generation.
PMID: 22144769 PMCID: PMC3229780 DOI: 10.4103/0253-7613.89821  Indian J Pharmacol. 2011 Nov;43(6):656-61. doi: 10.4103/0253-7613.89821. ncbi.nlm.nih.gov

Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation
B Dinda, I SilSarma, M Dinda, P Rudrapaul
Abstract
Ethnopharmacological relevance: Oroxylum indicum\ (L.) Kurz has been used for centuries as a traditional medicine in Asia in ethnomedicinal systems for the prevention and treatment of several diseases, such as jaundice, arthritic and rheumatic problems, gastric ulcers, tumors, respiratory diseases, diabetes, and diarrhea and dysentery, among others. The present review provides scientific evidence supporting the therapeutic potency of the plant for ethnomedicinal uses and identifies gaps for future research to facilitate commercial exploitation.
Methods: This review is based on available information on traditional uses and phytochemical, pharmacological, clinical and toxicity data for Oroxylum indicum that was collected from electronic (SciFinder, PubMed, Science Direct, and ACS, among others) and library searches.
Key finding: A variety of traditional medicinal uses of Oroxylum indicum in different Southeast and South Asian countries have been reported in books describing the uses of these plants. Phytochemical investigations of the different parts of the plant resulted in identification of approximately 111 compounds, among which flavonoids, naphthalenoids and cyclohexylethanoids are the predominant groups. The crude extracts and their isolates exhibit a wide spectrum of in vitro and in vivo pharmacological activities involving antimicrobial, anti-inflammatory, anti-arthritic, anticancer, anti-ulcer, hepatoprotective, antidiabetic, antidiarrheal and antioxidant activities. Flavonoids are the major constituents of all parts of the plant. From a toxicity perspective, only aqueous and ethanolic extracts of stem bark, root bark and fruits have been assessed and found to be safe. The major flavonoids of the stem bark, such as baicalein, chrysin and oroxylin A, were reported for the first time as natural flavonoids with potent inhibitory activity against endoprotease enzymes and proprotein convertases, which play a key role in the growth of cancer and in viral and bacterial infections. Flavonoids are the active components of bioactive extracts. Several Ayurvedic medicines have been formulated either singly using this plant or along with other herbs for the treatment of different diseases.
Conclusions: Pharmacological results have supported some traditional medicinal uses of Oroxylum indicum. Several extracts and their isolates have been reported to exhibit interesting pharmacological properties. These components could be useful as sources of modern medicines following future detailed studies to elucidate their underlying mechanisms, toxicity, synergistic effects and clinical trials. Attention should also be focused on pharmacological studies investigating the traditional uses of the plant, which have not been yet addressed, as well as clinical studies investigating commercial Ayurvedic medicines and other ethnomedicinal preparations in human subjects based on this plant to confirm the safety and quality of the preparations.
J Ethnopharmacol 2015 Feb 23;161:255-78. doi: 10.1016/j.jep.2014.12.027. Epub 2014 Dec 25. PMID: 25543018 pubmed.ncbi.nlm.nih.gov

Oroxylum indicum extract, at a physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice
Satyanarayana R Pondugula, Julia M Salamat, Kodye L Abbott, Patrick C Flannery, Mohammed Majrashi, Mohammed Almaghrabi, Manoj Govindarajulu, Sindhu Ramesh, Suneel K Onteru, Maninder Sandey, Chen-Che Huang, Kristina Gill, Natasha Narayanan, Edwin McElroy, Darshini Desai, Rishi Nadar, Timothy Moore, Kalyanam Nagabhushanam, Muhammed Majeed, Muralikrishnan Dhanasekaran
Abstract
Background: Botanical supplements have been proven to provide beneficial health effects. However, they can induce unintended adverse events such as hepatotoxicity. Oroxylum indicum extract (OIE, Sabroxy®) has several health benefits including anti-inflammatory, anti-arthritic, antifungal, antibacterial, and neuroprotective effects. It is currently unknown whether OIE has the potential to induce hepatotoxicity.
Purpose: In the current study, we sought to determine whether OIE can induce hepatotoxicity in C57BL/6J mouse model.
Methods: The male mice were fed powdered rodent food (control group) or powdered rodent food mixed with OIE (Sabroxy®, 500mg/kg) daily for 4 weeks. Following the treatment, we assessed liver histology and serum levels of biomarkers commonly associated with liver damage, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
Results: No significant alterations were observed in liver histology, and serum levels of ALT, AST, ALP, bilirubin, albumin, globulin and total protein in the OIE fed mice compared to the control mice.
Conclusion: Taken together, our results suggest that OIE, when fed at its physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice.
Nat Prod Commun 2021 May;16(5):10.1177/1934578x211016966. doi: 10.1177/1934578x211016966. Epub 2021 May 18. PMID: 34306298 PMCID: PMC8297712 pubmed.ncbi.nlm.nih.gov