Vitex negundo var cannabifolia. V. rotundifolia V. trifolia  Chinese chastetree, Five leaf Chastetree, Hemp leaved vitex    Family: Verbenaceae    
牡荆 Mǔ jīng, Huang jing zi   Ripe fruit- harvested in Autumn.
Nature: Neutral, warm     FLAVOR:  Acrid, bitter, fragrant, slightly bitter, pungent CHANNELS: Bladder, Liver, Stomach
FUNCTIONS
GROUP: Exterior clearing- Warming
1. Expel Sputum. Relieve cough. Calm down asthma. Resolves phlegm.[1] Eliminates moisture.[1] Alleviates diarrhea and dysentery.[1]
2. Clear Fevers.[1]
ACTIONS: Diaphoretic.[1]
INDICATIONS
1. Lung conditions: Chronic bronchitis. Treatment of cold, wheezing and coughing.[1]
2. Damp Heat- As a malaria preventive.[1]  Acute bacterial dysentery, gastroenteritis.[1] Heatstroke.[1]
3. Arthralgia.[1]
PATENT COMBINATIONS
- Flu and colds at the first stage: Exterior releasing- cooling- The diaphoretic action (sweating effect) moves circulation to the surface to clear invading microbes affecting the Lungs/throat- Gan mao ling.
五指柑 Huang jing ye Leaf




PREPARATIONS: Dried and pulverized fruits 6-9 g, mixed with boiled water each time for taking internally.[1]
 Decoction - Roots, leaves and fruit 15-30 g.[1] Dried leaf 15-30 g.[2]

Vitex negundo 牡荆油 Mǔ jīng yóu   Oil
FUNCTIONS
1. Expel sputum, relieve cough, calm down asthma.[2]
INDICATIONS
1. Chronic bronchitis.[2]
HABITAT: Found growing wild in uplands and roadsides.
DESCRIPTION: Deciduous shrub. Stem; oblong, multi-branching. Leaves; opposite, palmate-compound, usually 5 leaflets, leaflets oval, apexes long-acute, bases cuneate, margins serrated. Flowers; in summer, terminal light purplish flowers appearing to form panicle inflorescences. Drupe; globose, brown.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Research

Antiseptic activity and phenolic constituents of the aerial parts of Vitex negundo var. cannabifolia.
Ling TJ, Ling WW, Chen YJ, Wan XC, Xia T, Du XF, Zhang ZZ.
Abstract
Four phenolics, salviaplebeiaside, γ-tocopherol, chrysosplenol-D, and isovitexin, along with α-tocoquinone and β-sitosterol were isolated from the aerial parts of Vitex negundo var. cannabifolia. The isolation was performed using bio-assay tracking experiments. The structures of compounds 1-5 were established by spectroscopic means. The antibacterial activities of the compounds were assessed against Escherichia coli, Bacillus subtilis, Micrococcus tetragenus and Pseudomonas fluorescens. Chrysosplenol-D exhibited activities against all the four spoilage microorganisms.
PMID: 21088661 DOI: 10.3390/molecules15118469  Molecules. 2010 Nov 18;15(11):8469-77. doi: 10.3390/molecules15118469. ncbi.nlm.nih.gov

Vitex negundo inhibits cyclooxygenase-2 inflammatory cytokine-mediated inflammation on carrageenan-induced rat hind paw edema.
Chattopadhyay P, Hazarika S, Dhiman S, Upadhyay A, Pandey A, Karmakar S, Singh L.
Abstract
BACKGROUND:
Vitex negundo L. (Verbenaceae) is a hardy plant widely distributed in the Indian subcontinent and used for treatment of a wide spectrum of health disorders in traditional and folk medicine, some of which have been experimentally validated. In present study, we aimed to investigate the anti-inflammatory effects of V. negundo in carrageenan-induced paw edema in rats, and to investigate the probable mechanism of anti-inflammatory action.
MATERIALS AND METHODS:
Paw edema was produced by injecting 1% solution of carrageenan, and the paw volume was measured before and after carrageenan injection up to 5 h. V. negundo leaf oil was extracted using a Clevenger apparatus and administered by a trans-dermal route to Wistar rats and the percentage of inhibition of inflammation was observed using a Plethysmometer by comparing a compound aerosol-based formulation with 1 mg diclofinac diethylamine BP and 7 mg methyl salicylate IP/kg body weight served as a standard drug whereas paraffin oil served as the placebo group. After withdrawing of blood, serum was separated and cyclooxygenase (COX)-1 and COX-2 inhibitory activities were measured by the enzyme immuno assay (EIA) method by using a COX inhibitor screening assay kit.
RESULTS AND DISCUSSION:
V. negundo leaf oil significantly (P < 0.05) reduced the carrageenan-induced paw edema as compared to the placebo group (paraffin oil) and 1 mg diclofinac diethylamine BP and 7 mg methyl salicylate IP showed the maximum inhibition of paw edema as compared to the V. negundo leaf oil treated group and the control group. Also in the present study V. negundo leaf oil showed significantly (P < 0.05) inhibits COX-1 pathways rather than COX-2 pathways as compared to the V. negundo leaf oil treated group.
CONCLUSION:
It is suggested that the V. negundo leaf oil is a potent anti-inflammatory agent and acts via inhibition of COX-2 without much interfering COX-1 pathways.
PMID: 22923950 PMCID: PMC3424839 DOI: 10.4103/0974-8490.99072 Pharmacognosy Res. 2012 Jul;4(3):134-7. doi: 10.4103/0974-8490.99072. ncbi.nlm.nih.gov