Sanguisorba
officinalis. S. sinensis地榆
Dì yú Garden
burnet, Red
Bloodwort Family: Rosaceae PART USED: Root FLAVOR: Bitter, sour, harsh. CHANNELS:
Liver, Large Intestine FUNCTIONS- Mostly assistant herb GROUP: Regulating
Blood and Styptic
1. Cool Blood.[1] Counteract toxic
effects.[1,2] Styptic for gastrointestinal
tract.[3]
2. Clear fever.[1] Astringent.[3]
Antibiotic.[3] INDICATIONS
1. Gastro-intestinal bleeding: Bleeding hemorrhoids.[1,2]
Uterine bleeding.[1] Bleeding from stomach
and intestines. Tenesmus with discharge of blood, vaginal bleeding. Acute bacillary
dysentery.[1] Blood in stool from haemorrhoids
or ulcer.[3]
2. External application for burns-[1,2,3]
can add Shi gao. Also carbuncles. CONTRAINDICATIONS: Take care with weak Deficient conditions.[3]
Deficient Cold conditions.[3] PREPARATIONS:Decoction.
Roots 15-30 g for each dose. Or dried roots may be crushed and taken by mouth;
or sesame oil may be mixed with the powdered root for applying on external cuts
and injuries.[1] Dried root 9-15
g.[2,3]
- Chronic dysentery- use roasted Di yu HABITAT: Grows on uplands and plains. DESCRIPTION: Perennial herb. Perennial roots thick. Stem; erect, height
20-150 cm, finely angled and shallowly grooved. Leaves; alternate, oddly pinnate
compound, leaflets long oval, apexes obtuse, bases truncate, margins serrated.
Basal leaves; larger, with long petioles. Stem leaves; smaller, petioles almost
absent, bases clasping stem, stipules on both sides encircling. Flowers; in autumn,
dark purplish red terminal flowers, obovate or rounded, forming a spike inflorescence.
Achene; ovate and 4-angled. References
[1] Barefoot Doctor's Manual- 1977 Prepared
by the Revolutionary Health Committee of Hunan Province. Original Chinese manual-
Victor W. Sidel. Originally published by Dr Joseph Quin and the Fogarty International
centre, Bethdesda (1974). Madrona Publishers Seattle Washington ISBN 0-914842-52-8
[2] A Complete English Dictionary of Medicinal Terms in Chinese Acupuncture
and Herbalism 1981- Henry Lu Chinese Foundations of Natural Health- The Academy
of Oriental Heritage, Vancouver, Canada.
[3] Translation notes from Gary Seiford and Hocu Huhn - NSW College of Natural
Therapies. Sydney Australia. Images
1. jardindupicvert.com
2. [1] 3. pdh.cakeandeatitdesigns.com
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally. Constituents.
Flavonoids.[1,2]
Saponin. Sanguisorbine. Volatile oil.[1,2]
Tannin,[1,2,3] and related compounds;
sanguisorbic acid dilactone (a phenolic acid), sanguiins H1, H2 and H3 (ellagitannins).[3]
Methylglucoside gallates.[4] Galloyl
catechins and procyanidins.[5] Trimetic
hydrolysable tannin sanguiin H11,[8]
and 3,3',4-tri-O-methylellagic acid.[9] Root: Glycosides based on ursolic acid, known as sanguisorbins
A, B and E.[7] Galloyl hamameloses.[6] References
[1] British Herbal Pharmacopoeia 1983 Published by the British Herbal Medicine
Association ISBN 0 903032 07 4.
[2] Herbal Materia Medica Course Notes For Diploma of Naturopathy and Diploma
of Herbalism Students by Lydia Mottram.
[3] Nonaka, G. I. et al. (1982) J. Chem Soc. Perkin Trans. 10
(4), 1067
[4] Tanaka, T. et al. (1984) Chem. Pharm. Bull 32
(1), 117
[5] Tanaka, T. et al. (1983) Phytochem. 22 (11), 2575
[6] Nonaka, G. I. et al. (1984) Chem. Pharm. Bull. 32 (2) 483
[7] Pharmacology and Applications of Chinese Materia Medica Vol 1, Ed. H. Chan
and P. But, Pub. World Sicentific (1986) Singapore
[8] Tanake, T. el al. (1985) J. Chem Res (S) 6, 176
[9] Kosuga, T. et al. (1984) Chem. Pharm. Bull. 32
(11), 448
Research.
The antihemorrhagic effect has been demonstrated in animals, and has been shown
to be due at least in part to the 3,3'4-tri-O-methylellagic acid.[1]
Burnet has a therapeutic effect on burns and scalds, by reducing exudation, decreasing
tissue edema and reducing the incidence of infection. These effects were found
to be other factors as well as the tannins.[2]
It has a mild anti-emetic action and antimicrobial activity against a variety
of common pathogens.[2]
Clinical studies have confirmed its usefulness in bacillary dysentery, and topically
for skin diseases such as eczema and infected tinea pedis.[2]
It is also an ingredient of some Chinese compound preparations which have been
tested and found to be effective for cervical erosion, uterine bleeding, and gastrointestinal
hemorrhage.[2]
Burnet extract is also an ingredient of a dentifrice used for the prevention and
treatment of periodontal disease.[3] References
[1] Kosuga, T. et al. (1984) Chem.
Pharm. Bull. 32 (11), 448
[2] Pharmacology and Applications of Chinese Materia Medica Vol 1, Ed. H. Chan
and P. But, Pub. World Sicentific (1986) Singapore
[3] Sunstar Inc, (1980) Pat JP 80/120509 Japan
Sanguisorba officinalis L. Extracts Exert Antiobesity Effects in 3T3-L1
Adipocytes and C57BL/6J Mice Fed High-Fat Diets.
Jung DW, Lee OH2, Kang IJ. Abstract
The purpose of this study was to investigate the antiobesity effect of Sanguisorba
officinalis L. (SOL) in 3T3-L1 adipocytes and obese C57BL/6J mice. SOL was extracted
with water and 30%, 50%, 70%, and 100% ethanol (EtOH). 3T3-L1 adipocytes were
treated with SOL extracts (100?µg/mL) during the differentiation period.
Triglyceride (TG) accumulation was determined by Oil Red O staining, and the expression
of adipocyte-specific proteins was measured by Western blot analysis. C57BL/6J
mice were fed a high-fat diet to induce obesity and were orally administered SOL
50% ethanol extract (50, 100, and 200?mg/kg) for 8 weeks. Among the SOL extracts,
the 50% EtOH extract considerably inhibited TG accumulation through the downregulation
of PPAR?, C/EBPa, and SREBP-1c in 3T3-L1 adipocytes. In addition, the 50% ethanol
extract reduced body weight and adipose tissue weight and improved serum lipid
profiles through downregulation of PPAR?, C/EBPa, FABP4, and ACC and upregulation
of adiponectin and CPT-1 in obese C57BL/6J mice fed a high-fat diet. These results
suggested that the SOL 50% EtOH extract may have an antiobesity effect through
the regulation of transcription factors related to adipogenesis, lipogenesis,
and lipolysis.
PMID: 27309406 DOI: 10.1089/jmf.2016.3704 J Med Food. 2016 Aug;19(8):768-79.
doi: 10.1089/jmf.2016.3704. Epub 2016 Jun 16. ncbi.nlm.nih.gov
Extracts of medicinal herb Sanguisorba officinalis inhibit the entry of
human immunodeficiency virus type one. Liang J, Chen J, Tan Z, Peng J, Zheng X, Nishiura K, Ng J, Wang Z, Wang
D, Chen Z, Liu L. Abstract
Highly active antiretroviral therapy (HAART) has been successful in reducing HIV-1-associated
morbidity and mortality since its introduction in 1996. It, however, fails to
eradicate HIV-1 infection thoroughly. The high cost of life-long HAART and the
emergence of drug resistance among HIV-1-infected individuals have brought renewed
pressure for the discovery of novel antivirals and alternative medicines. Traditional
Chinese medicine (TCM) is one of the mainstreams of complementary and alternative
medicine, and serves as rich resources for new drug development. Despite almost
100 plant-derived compounds are in clinical trials, few target HIV-1 infection.
In this study, we discovered that extract of Sanguisorba officinalis (SOE) has
anti-HIV-1 activities. Using a cell-based assay and single-cycle luciferase reporter
viruses pseudotyped with envelopes from HIV-1 or control viruses, we found that
SOE exhibited significant inhibitory ability against both CCR5 and CXCR4 tropic
HIV-1 (ADA and HXB2) with respective IC50 values of 1.91±0.16 µg/ml
and 3.70±0.53 µg/ml. Interestingly, SOE also inhibited SIV infection
but failed to block vesicular stomatitis virus (VSV), SARS-CoV and influeunza
H5N1 pseudoviruses. Furthermore, we showed that SOE had no effects on post-entry
events of HIV-1 replication. It blocked entry by acting on viral envelope directly
because SOE pre-treatment with the virus but not with cell lines expressing viral
receptors showed the maximal inhibitory activity. In addition, SOE was able to
inhibit reverse-transcription-inhibitor-resistant viruses (K103N, Y188L, and K103N/Y188L/G190A)
and a protease-inhibitor-resistant strain (PI-2840). Our findings demonstrated
SOE as a novel and specific entry inhibitor, which shed lights on the discovery
of anti-HIV-1 drugs from traditional herbal medicines.
PMID: 25191092 PMCID: PMC4151571 DOI: 10.1016/j.jfda.2013.09.034 Yao Wu
Shi Pin Fen Xi. 2013 Dec;21(4):S52-S58.
ncbi.nlm.nih.gov