Omphalia lapidescens  Léi wán   Dry fungus nucleus  Family: Polyporaceae. 
A parasitic fungus found growing on roots of bamboo. Collected in autumn.
Nature: Cold   FLAVOR: Slightly bitter, acrid    TOXICITY: Slightly toxic.[1] CHANNELS: Stomach, Large intestine.
FUNCTIONS
GROUP: Antihelminthics
1. Expel parasites.[3] Eliminates marasmus.[1] Kills worms.[1]
INDICATIONS
1. Tape worms.[1,2] Hookworm.[1,2] Roundworm.[1,2] Marasmus.[1]
CONTRAINDICATIONS: Take with cautions if the patients suffer deficiency-cold of spleen and stomach with helminthic accumulation.[3]
PREPARATIONS: Decoction 3-9 g.[1] Dry fungus nucleus 15-20 g.[2]
Do not decoct this herb because it contains protease that will be easily broken at 60o C.[3]


References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.

Research

A PVP-extract fungal protein of Omphalia lapideacens and its antitumor activity on human gastric tumors and normal cells.
Chen YT1, Lu QY, Lin MA, Cheng DQ, Ding ZS, Shan LT.
Abstract
Omphalia lapidescens is an important medicinal fungus as well as traditional Chinese medicine used for disease treatment. It is mainly used as a vermifuge for anthelmintic therapy, but it has not been hitherto reported to possess antitumor activity. In this study, a purified bioactive protein in O. lapidescens (pPeOp) was obtained using polyvinylpyrrolidone (PVP) followed by gel filtration chromatography. To evaluate the in vitro antitumor activity of pPeOp in human gastric tumor cells (MC-4 and SGC-7901) and normal cells (MC-1), MTT assay and FCM assay were used and the morphological changes, cell viability, cell death rate and cell apoptosis rate of MC-4, SGC-7901 and MC-1 cells were estimated. The results showed that pPeOp could significantly reduce the cell viability of MC-4 and SGC-7901 cells in a concentration-dependent manner, with IC50 values of 236.05 and 156.28 µg/ml, respectively. The morphological observation also indicated a similar result. In FCM assays, a significant increase of cell death rate and cell apoptosis rate of the tumor cells were observed, indicating probable necrosis-inducing effects and/or apoptosis-inducing effects of pPeOp. Importantly, there was no significant effect of pPeOp on MC-1 cells in each assay, showing that pPeOp has no adverse effects on the normal cells. In conclusion, pPeOp is a newly discovered bioactive protein in O. lapidescens and this is the first report on antitumor activity of such a fungal protein. This may provide a meaningful basis for developing a new protein drug for treatment against cancer, especially gastric cancer.
PMID: 21894437 DOI: 10.3892/or.2011.1448  Oncol Rep. 2011 Dec;26(6):1519-26. doi: 10.3892/or.2011.1448. Epub 2011 Sep 5. ncbi.nlm.nih.gov