Albizia julibrissin. 合欢皮
Hé huān pí Persian silk tree, Tree of happiness,
Mimosa tree Family: Fabaceae
The plant is sensitive, the leaves folding together at night, as the Chinese name
implies. The leaves are edible. Considered to be an auspicious tree, promoting
agreement and affection, and therefore is given a place among domestic shrubbery.
PART USED: Dried bark-
peeled off in summer and autumn and dried in the sun. FLAVOR: Sweet, slightly fragrant, the taste is
light, slightly astringent, slightly tongue-tingling, and then there is discomfort
in the throat. ACTIONS
1. Tonic, vulnerary, sedative, anthelmintic and discutient (capable of dissipating
diseased matter).[2] FUNCTIONS GROUP: Calm Spirit- Mild
1. Calm down spirits.[1] Promoting joy,
assuaging sorrow, brightening the eye, and giving the desires of the heart.[2]
Grief as a result of a severe loss- Chinese people traditionally recommend.[3]
2. Activate Blood.[1]
3. Heal carbuncle.[1] Carbuncles, swellings,
and as a retentive in fractures and sprains- using a prepared decocted gummy extract.[2] PATENT COMBINATIONS - Deficiency of Heart Blood with disharmony between
Liver and Spleen: Nourishes the Heart
Blood and calms the Shen, regulates and tonifies the middle HeaterWheat
& Jujube- Gan mai da zao wan. PREPARATIONS: Bark:
9-15g.[5]
Traditionally, Albizia bark is soaked in water for at least 20-30 minutes then
decocted in non-metallic pots with water with one or more other herbs on a low-moderate
heat for around 20-30 mins.[5]
合欢花Hé huān huā
Flower FLAVOR: Sweet CHANNELS: Liver,
Stomach FUNCTIONS GROUP: Calm Spirit- Mild
The bark is thought to ‘anchor’ the spirit, while the flowers lighten it.[3]
1. Relieves Stagnant Liver Qi, promotes the flow of Qi in the collaterals, harmonizes
the Stomach and calms the Shen.[4] INDICATIONS
1. Insomnia, forgetfulness and irritability due to stuck emotions, especially
when accompanied by epigastric pain and feelings of pressure in the chest.[4] PREPARATIONS: Decoction
4.5-9g.[4] Flowers: 3-9.[5] References
[1] A Complete English Dictionary of Medicinal
Terms in Chinese Acupuncture and Herbalism 1981- Henry Lu Chinese Foundations
of Natural Health- The Academy of Oriental Heritage, Vancouver, Canada.
[2] Chinese Medicinal Herbs- Beatrice Bliss (1973) Compiled by Li Shi- Chen.
Translated and Researched by F. Porter Smith and G. A. Stuart. Geogetown Press,
San FranciscoISBN 0 914558005
[3] planetherbs.com/research-center
[4] americandragon.com
[5] herbalreality.com Images
1. en.wikipedia.org
by AnRo0002 cropped
by Beyond My Ken
CC0
2. activeherb.com
3. mt.sohu.com
Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally. Similar plants
Both He Huan Hua and the Cx. Albizziae
He Huan Pi, are sweet and neutral, augment the Heart and Spleen, remove constraint
and calm the Spirit. He Huan Pi has a slightly greater ability to invigorate
the Blood, stop pain and reduce swellings, while He Huan Hua moves Liver Qi,
and is better for soothing the Liver, unbinding the Stomach, promoting memory,
promoting sleep and brightening the eyes.[1] References
[1] americandragon.com
Albizia is considered very safe, although
caution should be taken when pregnant as it invigorates blood.[1] References
[1] herbalreality.com References
Anxiolytic-like effects of extracts from Albizzia julibrissin bark in
the elevated plus-maze in rats.
Kim WK, Jung JW, Ahn NY, Oh HR, Lee BK, Oh JK, Cheong JH, Chun HS, Ryu JH. Abstract
The purpose of the this study was to characterize the putative anxiolytic-like
effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated
plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally
administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before behavioral
evaluation in an EPM, respectively. Control rats were treated with an equal
volume of saline, and positive control rats buspirone (1 mg/kg). Single or repeated
treatment (for 7 days) of the water extract of Albizzia julibrissin (at 100
or 200 mg/kg) significantly increased time-spent and arm entries into the open
arms of the EPM, and decreased time-spent and arm entries in the closed arms
of the EPM versus saline controls (P < 0.05). However, no changes in the
locomotor activity and myorelaxant effect were seen in any group versus the
saline control. In addition, the anxiolytic-like effects of Albizzia julibrissin
extract were abolished by pindolol (10 mg/kg, i.p), a 5-HT(1A/1B) receptor antagonist.
These results suggest that Albizzia julibrissin might proved to be an effective
anxiolytic agent, and that it acts via the serotonergic nervous system.
PMID: 15464830 DOI: 10.1016/j.lfs.2004.05.024 Life Sci. 2004 Oct 22;75(23):2787-95.
ncbi.nlm.nih.gov
Total saponins from Albizia julibrissin inhibit vascular endothelial
growth factor-mediated angiogenesis in vitro and in vivo.
Cai W, Li Y, Yi Q, Xie F, Du B, Feng L, Qiu L. Abstract
Dried stem bark from Albizia julibrissin (AJ) is a highly valued Traditional
Chinese Medicine, which has been shown to suppress tumor growth and angiogenesis.
Total saponins from AJ (TSAJ) are one of the most bioactive components of AJ
extract. The present study evaluated the anti-tumor and anti-angiogenic effects
of TSAJ in vitro and in vivo. The anti-angiogenic activity of TSAJ was investigated
by measuring the effects on vascular endothelial growth factor (VEGF)-induced
proliferation, migration and tube formation of Ea.hy926 endothelial cells in
vitro. The expression levels of proteins associated with VEGF-induced angiogenesis
were determined by western blotting. Furthermore, in vivo Matrigel™ plug and
H22 hepatoma tumor models were used to verify the anti-angiogenic effects of
TSAJ. The present study demonstrated that TSAJ significantly inhibited VEGF-mediated
endothelial cell proliferation, migration and tube formation of Ea.hy926 cells
in vitro. The anti-angiogenic effects of TSAJ were modulated by suppression
of phosphorylated-(p-) focal adhesion kinase, p-Akt, and p-extracellular signal-regulated
kinase in the VEGF/VEGF receptor 2 (R2) signaling pathway. Furthermore, oral
administration of TSAJ significantly inhibited tumor growth and tumor-induced
angiogenesis, as well as the formation of functional vessels, in the Matrigel™
plug model. These results suggest that TSAJ may be a potential anti-angiogenic
agent that targets the VEGF/VEGFR2 signaling pathway, and inhibits tumor-induced
angiogenesis.
|PMID: 25607254 PMCID: PMC4368075 DOI: 10.3892/mmr.2015.3228 Mol Med Rep. 2015
May;11(5):3405-13. doi: 10.3892/mmr.2015.3228. Epub 2015 Jan 20. ncbi.nlm.nih.gov
Attenuation of brain mitochondria oxidative damage by Albizia julibrissin
Durazz: neuroprotective and antiemetic effects
Mohammad Ali Ebrahimzadeh, Hamed Fathi, Ali Ziar, Hamidreza Mohammadi Abstract
Medicinal plants, as new drugs, are considered for treatment of insomnia, anxiety,
depression, confusion, nausea, and vomiting symptoms. The current study aimed
to evaluate the neuroprotective and antiemetic effects of Albizia. julibrissin
Durazz. flower extract in the chickens. Emesis was induced by copper sulfate
and ipecac (60 and 600 mg/kg, orally, respectively) and the methanolic extract
(50, 100, and 200 mg/kg) were injected intraperitoneally (i.p.). Mitochondrial
function, lipid peroxidation (LPO), protein carbonyl (PC) content, and catalase
activity as biomarkers of oxidative damage were evaluated in the brain mitochondria.
All doses of extract showed significant (p < 0.001) antiemetic activity against
induced emesis by copper sulfate and ipecac. Brain mitochondria function (by
50, 100, and 200 mg/kg of extract) were increased 48%, 85%, and 90% against
emesis induced by ipecac and 32%, 18%, and 24% against emesis induced by copper
sulfate, respectively. LPO and PC contents were significantly decreased after
the administration of extract in emesis induced by copper sulfate and ipecac.
A significant decrease (p < 0.01) of CAT activity was observed in the extract
(200 mg/kg) group in emesis induced by copper sulfate in chickens brain mitochondria.
The present study suggests that the extract had antiemetic effects against emesis
induced by copper sulfate and ipecac in young chickens via peripheral and central
mechanisms. Neuroprotective effect of the extract could be due to the increase
in bioactive compounds, plasma antioxidants, or direct free radical scavenging
that could prevent lipid and protein alteration and impede the formation of
oxidative damage.
Drug Chem Toxicol . 2019 Mar;42(2):122-129. doi: 10.1080/01480545.2017.1413106.
Epub 2017 Dec 18. PMID: 29250976 pubmed.ncbi.nlm.nih.gov
Flavonol acylglycosides from flower of Albizia julibrissin and their
inhibitory effects on lipid accumulation in 3T3-L1 cells
Tadahiro Yahagi 1, Akihiro Daikonya, Susumu Kitanaka Abstract
Obesity is a serious health problem worldwide. We investigated the anti-obesity
effect of the flower of Albizia julibrissin DURAZZ. (Leguminosae). A 90% EtOH
extract of the flower inhibited adipogenesis in 3T3-L1 preadipocytes, as well
as the activity of glycerol-3-phosphate dehydrogenase (GPDH) activity. New flavonol
acylglycosides (1-4) and eighteen known compounds (5-22) were isolated by bioassay-directed
fractionation. These new glycosides were elucidated to be 3″-(E)-p-coumaroylquercitrin
(1), 3″-(E)-feruloylquercitrin (2), 3″-(E)-cinnamoylquercitrin (3), and 2″-(E)-cinnamoylquercitrin
(4) on the basis of spectroscopic and chemical analysis. These compounds inhibited
adipogenesis in 3T3-L1 preadipocytes. In particular, 2 exhibited potent inhibitory
effects on triglyceride accumulation. Furthermore, GPDH activity was inhibited
by 2. Additionally, 2 inhibited glucose uptake in 3T3-L1 adipocytes. These results
indicate that the 90% EtOH extract and compounds isolated from the flower of
A. julibrissin inhibit adipogenesis in 3T3-L1 preadipocytes and may have anti-obesity
effect through the inhibition of preadipocyte differentiation.
Chem Pharm Bull (Tokyo) . 2012;60(1):129-36. doi: 10.1248/cpb.60.129. PMID:
22223384 pubmed.ncbi.nlm.nih.gov
Effect of Albizia julibrissin water extracts on low-density lipoprotein
oxidization
Katherine Vaughn 1, Colt McClain, Danielle Julie Carrier, Sunny Wallace, Jerry
King, Shanmugam Nagarajan, Edgar Clausen Abstract
High-value phytochemicals could be extracted from biomass prior to the current
cellulosic pretreatment technologies (i.e., lime, ammonia, dilute acid, or pressurized
hot water treatments) provided that the extraction is performed with a solvent
that is compatible with the pretreatment. This work reports on the extraction
of flavonoids from Albizia julibrissin biomass. While extracting A. julibrissin
foliage with 50 degrees C water, 2.227 mg/g of hyperoside and 8.134 mg/g quercitrin
were obtained, which is in the realm of what was obtained with 60% methanol.
A. julibrissin foliage, flower, and whole plant extracts were tested in terms
of their potential to inhibit low-density lipoprotein (LDL) oxidization. The
highest inhibition was obtained with foliage water extracts, which were standardized
at 2.5 microM of flavonoids. Also, the 2.5 microM foliage water extract resulted
in a reduction from 43% to only 1% of the observed monocyte adherence. To have
commercial application, A. julibrissin water extracts should be devoid of toxicity.
The A. julibrissin foliage, flower, and whole plant water extracts were not
toxic to Vero 76 cells. In summary, A. julibrissin biomass can be extracted
with 50 degrees C water to yield an antioxidant stream, showing that it may
be possible to couple extraction of valuable phytochemicals to the cellulosic
pretreatment step.
J Agric Food Chem . 2007 Jun 13;55(12):4704-9. doi: 10.1021/jf063458e. Epub
2007 May 12. PMID: 17497875 pubmed.ncbi.nlm.nih.gov
Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila
Jui-Shu Chang, Hsin-Ping Liu, Jack Cheng, Chao-Jung Chen, Su-Lun Hwang, Chi-Chuan
Tseng, Lee-Fen Hsu, Wei-Yong Lin
Affiliations expand Abstract
In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese
herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate
cognitive functions, especially learning memory. In previous studies, A. julibrissin
exhibits sedative activity, antidepressant-like effects, and protection of learning
and memory against amnesia. However, whether A. julibrissin ameliorates memory
loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived
Drosophila model and olfactory associative learning-memory assay to test the
effects of A. julibrissin on sleep-deprivation induced memory loss. We found
that A. julibrissin ameliorated 3-hour memory but not 1-hour memory or instant
learning. The findings might be applied to an anticipated short-term sleep disturbance.
Evid Based Complement Alternat Med . 2019 Apr 1;2019:7395962. doi: 10.1155/2019/7395962.
eCollection 2019. PMID: 31057652 PMCID: PMC6463593 pubmed.ncbi.nlm.nih.gov