Agrimonia pilosa. 仙鶴草
Xiān hè cǎo- "Immortal crane grass" Hairy agrimony,
Shaggy Speedwell, Dragon Tooth Grass Family: Rosaceae
Pilosa means "hairy", in Latin.
FLAVOR: Bitter, biting CHANNELS:
Lung, Liver
FUNCTIONS- Assistant herb
GROUP: Regulating
Blood- Styptic
1. Antipyretic and eliminates Dampness.
2. Strengthens heart by regulating heart beat- over use will slow heart beat.[3]
INDICATIONS
1. All Bleeding ailments. Discharge of blood from mouth, hematemesis,[3]
hematuria,[3] tenesmus with hemafecia.[3]
2. Abdominal pain, sore throat, headache.
3. Hemafecia and mucoid dysentery, bloody and white discharge.
4. Heatstroke.
PREPARATIONS: Decoction.
Dried plant above ground 6-12 g.[2]
Whole plant 9-30 g.[1] 15-30
g.[3]
Inhibitory effect of Agrimonia pilosa Ledeb. on inflammation by suppression
of iNOS and ROS production.
Abstract
Herbal medicines including Agrimonia pilosa Ledeb. (APL) have been traditionally
used to treat inflammations including allergic disease as valuable medicinal
properties. To investigate the attenuating ability of APL on inflammation, the
NO release and ROS production, which play a key role in inflammatory and immune
responses, was first tested using in vitro assay. The 80% ethanol extract of
APL showed a significant activity to inhibit NO release and ROS production.
In additional extracts from 80% ethanol extract of APL, n-butanol (BuOH) extract
displayed the most potent anti-inflammatory effects based on in vitro assay.
The extract also significantly reduced nitric oxide in lipopolysaccharide-activated
RAW 264.7 macrophage cells (p < 0.05), and suppressed the nitric oxide synthase
(iNOS) expression, whereas the extract showed no inhibitory effect on cyclooxygenase-2
(COX-2) expression, suggesting that the BuOH extract of APL could reduce the
NO production through suppression of iNOS, but not COX-2. The BuOH extract also
showed a significant effect in a carrageenan-induced rat paw edema in vivo model,
consistent with our in vitro results. Our findings suggest that the BuOH extract
of APL shows a potential anti-inflammatory activity, substantiating its traditional
use in medicine.
Source- Jung CH1, Kim JH, Park S, Kweon DH, Kim SH, Ko SG. Immunol Invest. 2010
Jan;39(2):159-70. doi: 10.3109/08820130903501790. ncbi.nlm.nih.gov