Stephania
& Astragalus Fáng ji huáng qí wán FUNCTIONS GROUP: Expel Dampness 1. Tonifies Qi, strengthens the Spleen, promotes diuresis to relieve
edema, releases exterior pathogens. INDICATIONS
1. Deficiency of Qi and accumulation of Fluids or Dampness: Spontaneous
perspiration, aversion to wind, heavy seansation of the body, dysuria, edema.
T- pale with moist white coat P- thready or feeble floating 2. External attack by Wind: sweating, aversion to wind and dysuria 3. Deficiency affected by Wind and Damp 4. Edema due to Deficiency of Qi 5. Obesity: typically a female with water plumpness, white skin,
soft and flaccid muscles, sweating, easily fatigued, and edema after exercise. APPLICATIONS: Cardiac and chronic nephritic edema, arthralgia,
ascites, obesity. INGREDIENTS Stephania
tetrandra- 漢防己 Hàn fáng jǐ- "Mealy Fang ji" Stephania Astragalus
propinquus-黃耆Huáng qí-Astragalus Glycyrrhiza
uralensis- 甘草 Gān
cǎo- Chinese Licorice Zingiber
officinale- 生姜 Shēng jiāng- Fresh Ginger rhizome Ziziphus
jujuba, Z. vulgaris 大枣 Dà Zǎo-
Large date CANG
ZHU- Swordlike Atractylodes lancea CONTRAINDICATIONS: Yin deficiency and Damp Heat. Excess patterns
with acute edema COMMENTS: This formula expels Wind Dampness and is used mainly
for arthritis and body Fluid retention.
Research
Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang
in rodents
Yu-Chin LinChing-Wen ChangChi-Rei WuEmail author Abstract
Background
Fang-Ji-Huang-Qi-Tang (abbreviated as FJHQT), composed by six medicinal herbs
including Radix Stephania Tetrandra, Radix Astragali, Rhizoma Atractylodis Macrocephalae,
Radix Glycyrrhizae, Rhizoma Zingiberis and Fructus Ziziphi Jujubae, is a frequently
Chinese prescription for treating painful and inflammatory disorders such as rheumatoid
arthritis. When Radix Stephania Tetrandra was misused with Aristolochia species,
acute or chronic nephropathy caused by aristolochic acid was happened. Thus, the
present study was aimed to identify Radix Stephania Tetrandra and performed the
pharmacological and toxicological evaluation of FJHQT extract in rodents.
Methods
Radix Stephania Tetrandra was identified by macroscopic and microscopic observation,
and the content of tetrandrine in FJHQT extract was measured by high performance
liquid chromatography. Then, the pharmacological activities of FJHQT extract with
respect to clinical use was investigated with acetic acid-induced writhing response,
formalin-induced licking response and carrageenan-induced paw edema. Finally,
we evaluated the subacute toxicology of FJHQT extract after 28-day repeated oral
administration in rats.
Results
Radix Stephania Tetrandra was correctly used in FJHQT extract, and the content
of tetrandrine in FJHQT extract was 2.5 mg/g. FJHQT extract produced a pronounced
and dose-dependent antinociceptive and anti-inflammatory effects in three above
models. FJHQT extract after 28-day repeated administration did not caused any
hematological, biochemical and histological change in rats.
Conclusions
We suggest that FJHQT extract is a high safety index Chinese medicine for antinociceptive
and anti-inflammatory application when Radix Stephania Tetrandra was correctly
used in FJHQT. Its antinociceptive and anti-inflammatory mechanism might be related
to peripheral nociceptive pathway such as prostaglandins.
BMC Complementary and Alternative Medicine December 2015 Open
AccessResearch article Springerlink
Stephania
& Astragalus Fáng ji huáng qí wán