Tylophora
ovata.娃
儿藤属
Wá ér téng shǔ Toad
vine Family: Asclepiadaceae FLAVOR: Acrid TOXICITY:
Slightly toxic FUNCTIONS
1. Relieves flatus.[1]
2. Stops coughing, resolves phlegm.[1]
3. Promotes vomiting, breaks down clots.[1] INDICATIONS
1. Asthma and coughing.[1]
2. Traumatic injuries, rheumatoid backaches.[1]
3. Pain in the Stomach and abdomen.[1]
4. Poisonous snake - bites.[1] PREPARATIONS:
Decoction- Roots 9-15 g.[1] DESCRIPTION: Climbing vine. References
[1] Barefoot Doctor's Manual- 1977 Prepared by the Revolutionary Health Committee
of Hunan Province. Original Chinese manual- Victor W. Sidel. Originally published
by Dr Joseph Quin and the Fogarty International centre, Bethdesda (1974). Madrona
Publishers Seattle Washington ISBN 0-914842-52-8 Images
1. old.tcmwiki.com
2. [1] Inner Path can not take any responsibility for any adverse effects from the
use of plants. Always seek advice from a professional before using a plant medicinally.
Research
Investigations on secondary metabolites of endophyte Diaporthe sp. hosted
in Tylophora ovata [Article in Chinese]
Zhen Liu, Jing-Yi Zhao, Yong Li, Xiao-Xi Lyu, Yun-Bao Liu Abstract
One new compound (2S, 3S)-2,3-dihydroxybutyl 2-hydroxy-3,5,6-trimethylbenzoate
(1) and six known compounds xylariphthalide A (2), convolvulol (3), cis-4-hydroxy-6-deoxytalone
(4), phomoxydienes B (5), 5,6-dihydroxy-2,3,6-trimethylcyclohex-2-enone (6), trans-cyclo-(D-tryptophanyl-L-tyrosyl)
(7) were isolated from Diaporthe sp., an endophytic fungus hosted in the leaves
of the toxic Chinese folk medicine Tylophora ouata, using the combination methods
of silica gel column chromatography, medium-pressure ODS column chromatography
and RP-preparative HPLC. The structure of compound 1 was elucidated by NMR and
MS data analyses. The absolute configurations were established according to the
¹H-NMR data and exciton chirality method. Compound 1 inhibited the activation
of human lung fibroblasts MRC-5 cells by 64.0% at 10 μmol·L⁻¹. The MTT assay showed
that compounds 2 and 4 displayed cytotoxic activity against human tumor cell lines
BGC-823 cells with IC₅₀ values of 1.5 and 8.6 μmol·L⁻¹, respectively.
Zhongguo Zhong Yao Za Zhi 2018 Jul;43(14):2944-2949. doi: 10.19540/j.cnki.cjcmm.20180315.002.
PMID: 30111053 DOI: 10.19540/j.cnki.cjcmm.20180315.002 pubmed.ncbi.nlm.nih.gov
Isolation and biological activities of phenanthroindolizidine and septicine
alkaloids from the Formosan Tylophora ovata
Yue-Zhi Lee 1, Chun-Wei Huang, Cheng-Wei Yang, Hsing-Yu Hsu, Iou-Jiun Kang, Yu-Sheng
Chao, Ih-Sheng Chen, Hwan-You Chang, Shiow-Ju Lee Abstract
An investigation of alkaloids present in the leaves and stems of Tylophora ovata
led to the isolation of two new septicine alkaloids and one new phenanthroindolizidine
alkaloid, tylophovatines A, B, C (1, 2, and 5), respectively, together with two
known septicine and six known phenanthroindolizidine alkaloids. The structures
of the new alkaloids 1, 2, and 5 were established by means of spectroscopic analyses.
These eleven alkaloids show in vitro anti-inflammatory activities with IC₅₀ values
ranging from 84 nM to 20.6 μM through their suppression of nitric oxide production
in RAW264.7 cells stimulated by lipopolysaccharide and interferon-γ. Moreover,
these substances display growth inhibition in HONE-1, NUGC-3, HepG2, SF-268, MCF-7,
and NCI-H460 cancer cell lines, with GI₅₀ values ranging from 4 nM to 24.2 μM.
In addition, tylophovatine C (5) and 13a(S)-(+)-tylophorine (7) were found to
exhibit potent in vivo anti-inflammation activities in a rat paw edema model.
Finally, structure–activity relationships were probed by using the isolated phenanthroindolizidines
and septicines. Phenanthroindolizidines are suggested to be divided into cytotoxic
agents (e.g., 10 and 11) and anti-inflammation based anticancer agents (e.g.,
5–9).
Planta Med 2011 Nov;77(17):1932-8. doi: 10.1055/s-0030-1271199. Epub 2011 Jul
4. PMID: 21728149 DOI: 10.1055/s-0030-1271199 pubmed.ncbi.nlm.nih.gov
FLAVOR: Acrid TOXICITY:
Slightly toxic 
Research