[1] British Herbal Pharmacopoeia 1983 Published by the British Herbal Medicine
Association ISBN 0 903032 07 4.
[2] Potter's New Cyclopaedia of Botanical Drugs and Preparations R.C.
Wren Revised by Elizabeth M. Williamson and Fred J Evans. First published in
Great Britain in 1988 and reprinted in 1989 and 1994 by the C. W. Daniel Company
Limited. 1 Church Path, Saffron Walden Essex. Published 1988 Printed and bound
by Biddles, Guildford ISBN 085207 1973.
Images
1.
flowers.la.coocan.jp
2.
[3] Constituents.
Sesquiterpenes; polygodial in the leaves
and polygonal, isodrimeninol, isopolygodial and confertifolin in the seeds.[5,6]
Flavonoids; quercetin, kaemferol, isorhamnetin and rhamnesin.[7]
Isocoumarin; polygonolide.[8]
A blood coagulating glycoside and a water-soluble alkoid are present. Also
much tannin and some essential oil. Two flavonoids, pericarin and its 7-methyl
ether, have been isolated from the whole plant.[2,3,4]
References
[1] British Herbal Pharmacopoeia 1983 Published by the British Herbal Medicine
Association ISBN 0 903032 07 4.
[2] R. Hegnauer, Chemotaxonomie der Pflanzen, Vol. 6, Birkhauser Verlag, Basel,
1973
[3] L.J. Webb, Guide to the Medicinal and Poisonous Plants of Queensland,
CSIRO Bulletin No. 232; Government Printer, Melbourne, 1948
[4] L.J. Webb, Australian Phytochemical Survey, Part 2, CSIRO Bulletin No.
268; Government Printer, Melbourne, 1952
[5] Barnes, C.S. and Loder, J.W. (1962) Aust. J. Chem. 15, 322
[6] Asakawa, Y. And Takemoto, T. (1979) Experientia 35, 1429
[7] Kifakh, W.Y. and Blinova, K.F. (1984) Khim. Prir. Soed. 5, 658
[8] Furuta, T. et al. (1986) Phytochem. 25 (2), 517
Research
The juice is hemostatic (if somewhat irritant) and has been used to treat sores
on horses.
[1]
References
[1] L.J. Webb, Guide to the Medicinal and Poisonous Plants of Queensland, CSIRO
Bulletin No. 232; Government Printer, Melbourne, 1948
Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin
and isorhamnetin, activate the Wnt/ß-catenin pathway and inhibit adipocyte
differentiation of 3T3-L1 cells.
Lee SH, Kim B, Oh MJ, Yoon J, Kim HY, Lee KJ, Lee JD, Choi KY.
Abstract
Obesity, which is related to metabolic syndrome and is associated with liver
disease, represents an epidemic problem demanding effective therapeutic strategies.
Evidence shows that the Wnt/ß-catenin pathway is closely associated with
obesity and that small molecules regulating the Wnt/ß-catenin pathway
can potentially control adipogenesis related to obesity. Eleven plant extracts
activating the Wnt/ß-catenin pathway were screened by using HEK 293-TOP
cells retaining the Wnt/ß-catenin signaling reporter gene. An extract
of Persicaria hydropiper (L.) Spach was found to activate Wnt/ß-catenin
signaling. P. hydropiper is grown worldwide in temperate climates and is found
widely in Southeast Asia. The P. hydropiper extract inhibited the differentiation
of adipocyte 3T3-L1 cells. Isoquercitrin and isorhamnetin, constituents of P.
hydropiper, also activated Wnt/ß-catenin signaling and suppressed the
differentiation of 3T3-L1 cells. These results indicate that isoquercitrin in
P. hydropiper suppresses the adipogenesis of 3T3-L1 cells via the inhibition
of Wnt/ß-catenin signaling. P. hydropiper and isoquercitrin may therefore
be potential therapeutic agents for obesity and its associated disorders.
PMID: 21413092 DOI: 10.1002/ptr.3469 Phytother Res. 2011 Nov;25(11):1629-35.
doi: 10.1002/ptr.3469. Epub 2011 Mar 17.
ncbi.nlm.nih.gov
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper
in mice.
Khatun A, Imam MZ, Rana MS.
Abstract
BACKGROUND:
Persicaria hydropiper (Linn.) Delarbre is a common plant of Polygonaceae family
commonly called Bishkatali in Bangladesh. Leaves of the plant are traditionally
used in the treatment of rheumatic pain, gout, and skin diseases such as ringworms,
scabies, boils, abscesses, carbuncles, bites of snakes, dogs or insects. This
study evaluated the antinociceptive effect of the methanol extract of P. hydropiper
leaves (MEPH).
METHODS:
The antinociceptive activity of MEPH was investigated using heat-induced (hot-plate
and tail-immersion test) and chemical-induced (acetic acid, formalin, glutamic
acid, cinnamaldehyde) nociception models in mice at 25, 50, and 75 mg/kg doses.
Involvement of opioid system, cyclic guanosine monophosphate (cGMP) pathway,
and ATP-sensitive K(+) channel pathway were also tested using naloxone, methylene
blue and glibenclamide respectively.
RESULTS:
MEPH showed antinociceptive activity in both heat- and chemical induced pain
models. In both hot plate and tail immersion tests MEPH significantly increases
the latency to the thermal stimuli. In acetic acid-induced writhing test the
extract inhibited the number of abdominal writhing. Likewise, MEPH produced
significant dose-dependent inhibition of paw licking in both neurogenic and
inflammatory pain induced by intraplantar injection of formalin. Besides, MEPH
also significantly inhibited the glutamate-induced pain and cinnamaldehyde-induced
pain in mice. It was also clear that pretreatment with naloxone significantly
reversed the antinociception produced by MEPH in hot plate and tail immersion
test suggesting the involvement of opioid system in its effect. In addition,
administration of methylene blue, a non specific inhibitor of NO/guanylyl cyclase,
enhanced MEPH induced antinociception while glibenclamide, an ATP-sensitive
K(+) channel antagonist, could not reverse antinociceptive activity induced
by MEPH.
CONCLUSION:
Based on the results of the current study it can be said that MEPH possesses
significant antinociceptive activity which acts in both peripheral and central
mechanisms.
PMID: 25888297 PMCID: PMC4363189 DOI: 10.1186/s12906-015-0558-y BMC Complement
Altern Med. 2015 Mar 13;15:63. doi: 10.1186/s12906-015-0558-y.
ncbi.nlm.nih.gov
