Collinsonia canadensis.  Stone root  Family Labiatae  
PART USED: Rhizome- collected in the Autumn.
TASTE: Bitter and unpleasant. Pungent   ODOR: Slight
ACTIONS
GROUP: The circulation system - Herbs for the veins & peripheral circulation.
1. Antilithic.[1] Litholytic.[1]
2. Diuretic.[1,2,3,4]
3. Astringent.[4] Stomachic.[4]
4. Mild Diaphoretic.[1]
5. Antispasmodic.
6. Tonic.[4]
7. Sedative stomachic. Stomachic.
INDICATIONS
1. Urinary stones or gravel.[4] Lithuria.[1] Edema. Bladder catarrh.
2. Hemorrhoids. Disorders of the rectum. Varicose veins.
3. Leukorrhea.
SPECIFIC INDICATIONS: Urinary calculus.[1] Kidney complaints.[4]
COMBINATIONS
- Urinary stone or gravel, use with Parsely Piert, Gravel Root and Hydrangea.
PREPARATIONS: 3X/day
Dried root  1-4 g, or as decoction 1:20.[1]
Fluid extract   1:1  25% alcohol  1-4 ml.[1,4]
Tincture  (BPC 1934) 1:5  40%  2-8 ml.[1,4] 

DESCRIPTION: Rhizome greyish-brown, very hard, up to 8 cm long, with knotty, short, irregular branches and numerous shallow stem scars. Bark; very thin. Numerous brittle rootlets may be attached.
ORIGIN: Canada.
References
Inner Path can not take any responsibility for any adverse effects from the use of plants. Always seek advice from a professional before using a plant medicinally.
Constituents
Research

Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease
In book: Naturally Occurring Chemicals Against Alzheimer's Disease
Fawzi M. Mahomoodally, Preethisha Devi Dursun, Katharigatta Narayanaswamy Venugopala
Abstract
Collinsonia canadensis L., also known as richweed or stone root, is a perennial plant reported to be native to eastern North America. Reports tend to show that richweed has a long-standing use as a medicinal plant to treat and/or manage a panoply of human diseases. Several bioactive compounds have been isolated from C. canadensis, which have been found to be beneficial in the management of Alzheimer’s disease (AD). Its main mode of action in neurodegenerative diseases might be ascribed to its antiinflammatory activities, in which the combination of major phenolic compounds from Collinsonia extract showed significant inhibition of lipopolysaccharide-stimulated nitrite production. Interestingly, C. canadensis has been found to prevent the breakdown of acetylcholine via inhibition of acetylcholinesterase, a key clinical enzyme involved in neurodegenerative diseases such as AD. Other bioactive compounds from this plant, namely thymol, in the range of 0.5–2.0 mg/kg, have shown to inhibit cognitive impairments caused by the heightened level of amyloid beta (Aß) or cholinergic hypofunction in Aß. Another compound from C. canadensis, carvacrol, was reported to exert 10 times stronger acetylcholinesterase inhibitory activity than thymol. The bioactive composition of C. canadensis shows promising avenues for research geared toward the management of AD.
February 2017 DOI: 10.1016/B978-0-12-819212-2.00031-1 researchgate.net